Once Daily Amoxicillin Therapy for the Treatment of Group A Beta-Hemolytic Streptococcal (GABHS) Pharyngitis • 699

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Treatment of streptococcal pharyngitis with once-daily compared with twice-daily amoxicillin: a noninferiority trial.

BACKGROUND Two relatively small previous studies comparing once-daily amoxicillin with conventional therapy for group A streptococcal (GAS) pharyngitis reported similar rates of bacteriologic success for each treatment group. The purpose of this study was to further evaluate once-daily amoxicillin for GAS pharyngitis in a larger study. METHODS In a single pediatric practice, from October thro...

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Late-onset Rash in Patients with Group A Beta-hemolytic Streptococcal Pharyngitis Treated with Amoxicillin

We observed late-onset rashes in patients with group A beta-hemolytic streptococcal (GAS) pharyngitis. Of 1028 patients with GAS pharyngitis, which was principally treated with amoxicillin, we evaluated those who developed a late-onset rash and excluded those with scarlet fever alone. Twenty-one patients developed a rash (2.0%, 95% confidence interval, 1.3-3.1%), 7 to 20 days (median, 8 days) a...

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Management of Group A beta-hemolytic streptococcal pharyngitis.

Bacteria are responsible for approximately 5 to 10 percent of pharyngitis cases, with group A beta-hemolytic streptococci being the most common bacterial etiology. A positive rapid antigen detection test may be considered definitive evidence for treatment; a negative test should be followed by a confirmatory throat culture when streptococcal pharyngitis is strongly suspected. Treatment goals in...

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Treatment strategies for group A streptococcal pharyngitis.

In the recent, nicely done study by Needham et al. (2) concerning the impact of a rapid group A streptococcal antigen assay on physician usage of appropriate antibiotics, there are two areas of concern. (i) In the abstract, the authors state that if the rapid antigen test alone had guided therapeutic choice, an appropriate course of antibiotics would have been prescribed for 95% of the patients...

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Treatment Challenges of Group A Beta-hemolytic Streptococcal Pharyngo-Tonsillitis

Introduction  Despite its in vitro efficacy, penicillin often fails to eradicate Group A β-hemolytic streptococci (GABHS) from patients with acute and relapsing pharyngo-tonsillitis (PT). Objective  This review of the literature details the causes of penicillin failure to eradicate GABHS PT and the therapeutic modalities to reduce and overcome antimicrobial failure. Data Synthesis  The causes o...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1997

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-199704001-00719